Sign in or Register   Sign in or Register
  |  

Rabbit Anti-PDE4B Recombinant Antibody (D7R1Y) (CBMAB-CP1902-LY)

The product is antibody recognizes PDE4B. The antibody D7R1Y immunoassay techniques such as: WB,IP.
See all PDE4B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D7R1Y
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu61 of human PDE4B protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphodiesterase 4B
Introduction
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Entrez Gene ID
Human5142
Mouse18578
Rat24626
UniProt ID
HumanQ07343
MouseQ9QXI7
RatP14646
Alternative Names
Phosphodiesterase 4B; Phosphodiesterase 4B; CAMP-Specific (Phosphodiesterase E4 Dunce Homolog; Drosophila); CAMP-Specific 3;5-Cyclic Phosphodiesterase 4B; DPDE4; Phosphodiesterase 4B; CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4); Phosphodiesterase E4 Dunce Homolog (Drosophila); Phosphodiesterase 4B; CAMP-Specific;
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978).
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epinephrine stimulusISS:BHF-UCL
Cellular response to lipopolysaccharideISS:BHF-UCL
Cellular response to xenobiotic stimulusISS:BHF-UCL
Leukocyte migrationISS:BHF-UCL
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processIEA:Ensembl
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Neutrophil chemotaxisISS:BHF-UCL
Neutrophil homeostasisISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionISS:BHF-UCL
Regulation of high voltage-gated calcium channel activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Isoform PDE4B5
Cytoplasm
Cell membrane
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-PDE4B Recombinant Antibody (D7R1Y)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare