Mouse Anti-PDE4B Recombinant Antibody (3B12) (CBMAB-P1215-YC)

Name: Mouse Anti-PDE4B Recombinant Antibody (3B12)
SKU: CBMAB-P1215-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3B12

Application

FC, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphodiesterase 4B

Introduction

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

5142

UniProt ID

Q07343

Alternative Names

Phosphodiesterase 4B; Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila); CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B; DPDE4; Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4); Phosphodiesterase E4 Dunce Homolog (Drosophila); Phosphodiesterase 4B, CAMP-Specific;

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978).
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Biological Process

cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epinephrine stimulusISS:BHF-UCL
Cellular response to lipopolysaccharideISS:BHF-UCL
Cellular response to xenobiotic stimulusISS:BHF-UCL
Leukocyte migrationISS:BHF-UCL
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processIEA:Ensembl
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Neutrophil chemotaxisISS:BHF-UCL
Neutrophil homeostasisISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionISS:BHF-UCL
Regulation of high voltage-gated calcium channel activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Isoform PDE4B5
Cytoplasm
Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PDE4B Recombinant Antibody (2B10) (CAT#: CBMAB-P1212-YC)

Mouse Anti-PDE4B Recombinant Antibody (3A10) (CAT#: CBMAB-P1214-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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