PFKP

This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants.

phosphofructokinase, platelet

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Canonical glycolysisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to leukemia inhibitory factorIEA:Ensembl
Fructose 1,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose 6-phosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm

Phosphorylation at Ser-386 promotes interaction with ATG4B.
GlcNAcylation decreases enzyme activity.