PFKP

This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants.
Full Name
phosphofructokinase, platelet
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Biological Process
Canonical glycolysisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to leukemia inhibitory factorIEA:Ensembl
Fructose 1,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose 6-phosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylation at Ser-386 promotes interaction with ATG4B.
GlcNAcylation decreases enzyme activity.
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Anti-PFKP antibodies

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Rabbit Anti-PFKP Recombinant Antibody (D2E5) (CBMAB-CP1941-LY)

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Target: PFKP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D2E5
Application*: WB, IP, IF (IC)
Datasheet SDS

Mouse Anti-PFKP Recombinant Antibody (3A12) (CBMAB-P1519-YC)

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Target: PFKP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A12
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-PFKP Recombinant Antibody (1D6) (CBMAB-P1518-YC)

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Target: PFKP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 1D6
Application*: WB, F, IH, IC, IF, P
Datasheet SDS

Mouse Anti-PFKP Recombinant Antibody (1A11) (CBMAB-P1517-YC)

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Target: PFKP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A11
Application*: F, IF, IH, WB
Datasheet SDS

Rabbit Anti-PFKP Recombinant Antibody (EG1730) (CBMAB-EN2068-LY)

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Target: PFKP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1730
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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