PIK3R6

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. [provided by RefSeq]

Full Name

phosphoinositide-3-kinase, regulatory subunit 6

Function

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Biological Process

AngiogenesisIEA:UniProtKB-KW
G protein-coupled receptor signaling pathwayISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAP kinase activityISS:UniProtKB
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Cytoplasm
Cell membrane
Translocated to the plasma membrane in a Ras-dependent manner.