Mouse Anti-PIK3R6 Recombinant Antibody (5E10) (CBMAB-P1833-YC)

Name: Mouse Anti-PIK3R6 Recombinant Antibody (5E10)
SKU: CBMAB-P1833-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5E10

Application

WB, IP, IF

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphoinositide-3-kinase, regulatory subunit 6

Introduction

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors.

Entrez Gene ID

146850

UniProt ID

Q5UE93

Alternative Names

Phosphoinositide-3-Kinase Regulatory Subunit 6; P84 PI3K Adapter Protein; P84 PIKAP; C17orf38; P87PIKAP; P87 Phosphoinositide 3-Kinase Gamma (PI3Kg) Adapter Protein; Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KDa; Phosphoinositide-3-Kinase, Regulatory Subunit 6;

Function

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Biological Process

AngiogenesisIEA:UniProtKB-KW
G protein-coupled receptor signaling pathwayISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAP kinase activityISS:UniProtKB
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Cytoplasm
Cell membrane
Translocated to the plasma membrane in a Ras-dependent manner.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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