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Mouse Anti-PIK3R6 Recombinant Antibody (1G16) (CBMAB-A6690-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G16
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PIK3R6 (NP_001010855, 661 a.a. ~ 754 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoinositide-3-kinase, regulatory subunit 6
Introduction
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. [provided by RefSeq]
Entrez Gene ID
146850
UniProt ID
Q5UE93
Alternative Names
C17orf38; DKFZp666P158; FLJ34500; HsT41028; p84; p87(PIKAP); p87PIKAP
Function
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Biological Process
AngiogenesisIEA:UniProtKB-KW
G protein-coupled receptor signaling pathwayISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAP kinase activityISS:UniProtKB
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:CACAO
Cellular Location
Cytoplasm
Cell membrane
Translocated to the plasma membrane in a Ras-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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