PLA2G4F

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

Full Name

phospholipase A2 group IVF

Function

Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256).
Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256).
Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256).
In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).

Biological Process

Arachidonic acid secretionIEA:Ensembl
Cellular response to antibioticIEA:Ensembl
Cellular response to organic cyclic compoundIEA:Ensembl
Glycerophospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylglycerol acyl-chain remodelingTAS:Reactome
Prostaglandin biosynthetic processIEA:Ensembl

Cellular Location

Cytoplasm, cytosol
Cell membrane
Mitochondrion