PLIN2

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.
Full Name
perilipin 2
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Long-chain fatty acid transportIEA:Ensembl
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Response to organic cyclic compoundIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Membrane
Lipid droplet
PTM
Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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Anti-PLIN2 antibodies

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Mouse Anti-PLIN2 Recombinant Antibody (201) (CBMAB-AP181LY)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 201
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-PLIN2 Antibody (10BA7) (CBMAB-1490CQ)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA7
Application*: E, WB
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (CBT2547) (V2LY-0625-LY2833)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2547
Application*: IH
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (CBT3342) (V2LY-0625-LY28)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3342
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (CF013) (CBMAB-FT465LY)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF013
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (ADPN1-1) (CBMAB-P2130-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: ADPN1-1
Application*: F, WB
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (ADFP/1493) (CBMAB-P2129-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: ADFP/1493
Application*: E, P, IF, IC
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (ADFP/1366) (CBMAB-P2128-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: ADFP/1366
Application*: E, P, IF, IC
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (ADFP/1365) (CBMAB-P2127-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ADFP/1365
Application*: WB, F, IC, IF, P
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (2C5A3) (CBMAB-P2126-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C5A3
Application*: WB, E, IH, IC, IF, P
Datasheet SDS

Mouse Anti-PLIN2 Recombinant Antibody (AP125) (CBMAB-A4668-YC)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat
Clone: AP125
Application*: C, P, WB
Datasheet SDS

Mouse Anti-PLIN2 Antibody (10BA6) (CBMAB-1489CQ)

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Target: PLIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10BA6
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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