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PON3

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
Full Name
Paraoxonase 3
Function
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Biological Process
Aromatic compound catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Carboxylic acid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Coumarin catabolic processIEA:Ensembl
Establishment of localization in cellIEA:Ensembl
Negative regulation of superoxide anion generationIEA:Ensembl
Phenylacetate catabolic processIEA:Ensembl
Renal sodium ion transportIEA:Ensembl
Response to toxic substanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
PTM
The signal sequence is not cleaved.
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Anti-PON3 antibodies

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Mouse Anti-PON3 Recombinant Antibody (CBXS-0060) (CBMAB-S3061-CQ)

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Target: PON3
Host: Mouse
Specificity: Human
Clone: CBXS-0060
Application*: WB, IC, P, C, E
Datasheet SDS

Rat Anti-PON3 Recombinant Antibody (CBYC-P516) (CBMAB-P2405-YC)

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Target: PON3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYC-P516
Application*: WB
Datasheet SDS

Mouse Anti-PON3 Recombinant Antibody (1F12) (CBMAB-P2404-YC)

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Target: PON3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F12
Application*: WB, IH
Datasheet SDS

Rabbit Anti-PON3 Recombinant Antibody (BA0220) (CBMAB-0686CQ)

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Target: PON3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: BA0220
Application*: WB
Datasheet SDS

Mouse Anti-PON3 Recombinant Antibody (5G11) (CBMAB-0685CQ)

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Target: PON3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5G11
Application*: P, WB, IF
Datasheet SDS

Rat Anti-PON3 Recombinant Antibody (MM1075-29P7) (CBMAB-0684CQ)

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Target: PON3
Host: Rat
Antibody Isotype: IgG2
Specificity: Human, Mouse, Rat
Clone: MM1075-29P7
Application*: WB
Datasheet SDS

Rabbit Anti-PON3 Recombinant Antibody (BA0221) (CBMAB-0683CQ)

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Target: PON3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0221
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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