PPM1F

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq]

Full Name

PPM1F

Function

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

Biological Process

Cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein transportManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-serine dephosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of growthManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein localizationManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

cytosol
nucleus
perinuclear region of cytoplasm
protein-containing complex