PPP3CB

PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP3CB include Pancreatic Ductal Adenocarcinoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydrolase activity. An important paralog of this gene is PPP3CA.

protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:19154138, PubMed:26794871).
Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).
Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138).
Dephosphorylates DARPP32 (PubMed:19154138).
Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity).
May play a role in skeletal muscle fiber type specification (By similarity).

Axon extensionManual Assertion Based On ExperimentTAS:UniProtKB
Calcineurin-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Calcium-ion regulated exocytosisISS:UniProtKB
DephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Heart developmentIEA:Ensembl
LearningManual Assertion Based On ExperimentTAS:UniProtKB
Locomotion involved in locomotory behaviorIEA:Ensembl
LymphangiogenesisIEA:Ensembl
MemoryManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of signalingISS:UniProtKB
Negative regulation of T cell mediated cytotoxicityIEA:Ensembl
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationISS:UniProtKB
Regulation of insulin secretionISS:UniProtKB
Regulation of synaptic plasticityManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of synaptic vesicle endocytosisIEA:Ensembl
Response to cytokineIEA:Ensembl
Signal transduction1 PublicationNAS:UniProtKB
Skeletal muscle fiber developmentISS:UniProtKB
T cell activationManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl
T cell homeostasisIEA:Ensembl
T cell mediated cytotoxicityIEA:Ensembl
T cell proliferation1 PublicationNAS:UniProtKB

Cytoplasm