PPP3CB

PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP3CB include Pancreatic Ductal Adenocarcinoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydrolase activity. An important paralog of this gene is PPP3CA.

Full Name

protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:19154138, PubMed:26794871).
Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).
Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138).
Dephosphorylates DARPP32 (PubMed:19154138).
Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity).
May play a role in skeletal muscle fiber type specification (By similarity).

Biological Process

Axon extensionManual Assertion Based On ExperimentTAS:UniProtKB
Calcineurin-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Calcium-ion regulated exocytosisISS:UniProtKB
DephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Heart developmentIEA:Ensembl
LearningManual Assertion Based On ExperimentTAS:UniProtKB
Locomotion involved in locomotory behaviorIEA:Ensembl
LymphangiogenesisIEA:Ensembl
MemoryManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of signalingISS:UniProtKB
Negative regulation of T cell mediated cytotoxicityIEA:Ensembl
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationISS:UniProtKB
Regulation of insulin secretionISS:UniProtKB
Regulation of synaptic plasticityManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of synaptic vesicle endocytosisIEA:Ensembl
Response to cytokineIEA:Ensembl
Signal transduction1 PublicationNAS:UniProtKB
Skeletal muscle fiber developmentISS:UniProtKB
T cell activationManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl
T cell homeostasisIEA:Ensembl
T cell mediated cytotoxicityIEA:Ensembl
T cell proliferation1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm