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PPY

PPY is a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa.
Full Name
pancreatic polypeptide
Function
Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
The physiological role for the icosapeptide has not yet been elucidated.
Biological Process
Feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted

Anti-PPY antibodies

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Target: PPY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P584
Application*: WB, IC, P, C, E
Target: PPY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P583
Application*: E, WB, F
Target: PPY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B-2
Application*: WB, IP, IF, E
Target: PPY
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P582
Application*: WB
Target: PPY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6
Application*: E
Target: PPY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 327
Application*: WB
Target: PPY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G5D12
Application*: WB, F, E, MC
Target: PPY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C10
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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