PRDX4

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
Full Name
peroxiredoxin 4
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationIEA:Ensembl
I-kappaB phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of male germ cell proliferationIEA:Ensembl
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIEA:Ensembl
Protein maturation by protein foldingIEA:Ensembl
Reactive oxygen species metabolic processIEA:Ensembl
Response to oxidative stressIEA:Ensembl
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
Endoplasmic reticulum
Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.
PTM
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
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Anti-PRDX4 antibodies

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Mouse Anti-PRDX4 Recombinant Antibody (4C3) (CBMAB-A7013-LY)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C3
Application*: WB, E
Datasheet SDS

Mouse Anti-PRDX4 Recombinant Antibody (9A3) (CBMAB-P2745-YC)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A3
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-PRDX4 Recombinant Antibody (3A1) (CBMAB-P2744-YC)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A1
Application*: WB, IP, IC
Datasheet SDS

Mouse Anti-PRDX4 Recombinant Antibody (2C12) (CBMAB-P2743-YC)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2C12
Application*: E, P, WB
Datasheet SDS

Mouse Anti-PRDX4 Recombinant Antibody (1A1) (CBMAB-P2742-YC)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1A1
Application*: IP
Datasheet SDS

Human PRDX4 ELISA Kit (V2LY-0626-LY3539)

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Target: PRDX4
Sensitivity: 0.18 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Prdx4 ELISA Kit (V2LY-0626-LY1832)

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Target: Prdx4
Sensitivity: 0.051 ng/mL
Detection Range: 0.1-38 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Anti-PRDX4 Recombinant Antibody (CF350) (CBMAB-FT151LY)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF350
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-PRDX4 Antibody (10BA21) (CBMAB-1502CQ)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10BA21
Application*: E, WB
Datasheet SDS

Mouse Anti-PRDX4 Antibody (10BA19) (CBMAB-1500CQ)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10BA19
Application*: E, P, IH, M, WB
Datasheet SDS

Mouse Anti-PRDX4 Antibody (10BA18) (CBMAB-1499CQ)

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Target: PRDX4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA18
Application*: E, P, IH, M, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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