Mouse Anti-PRDX4 Antibody (10BA21) (CBMAB-1502CQ)

Name: Mouse Anti-PRDX4 Antibody (10BA21)
SKU: CBMAB-1502CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

10BA21

Application

ELISA, WB

Immunogen

Synthetic Peptide (QITLNDLPVGR)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

peroxiredoxin 4

Introduction

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. Diseases associated with PRDX4 include Scurvy and Cryptorchidism. Among its related pathways are Selenium Micronutrient Network and Prostaglandin 2 biosynthesis and metabolism FM.

Entrez Gene ID

10549

UniProt ID

Q13162

Alternative Names

PRX-4; AOE372; AOE37-2; HEL-S-97n

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Biological Process

Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationIEA:Ensembl
I-kappaB phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of male germ cell proliferationIEA:Ensembl
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIEA:Ensembl
Protein maturation by protein foldingIEA:Ensembl
Reactive oxygen species metabolic processIEA:Ensembl
Response to oxidative stressIEA:Ensembl
SpermatogenesisIEA:Ensembl

Cellular Location

Cytoplasm
Endoplasmic reticulum
Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.

PTM

The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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