Sign in or Register   Sign in or Register
  |  

Mouse Anti-PRDX4 Antibody (10BA18) (CBMAB-1499CQ)

This product is a mouse antibody that recognizes PRDX4. The antibody 10BA18 can be used for immunoassay techniques such as: ELISA, IHC-P, IHC, MA, WB.
See all PRDX4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10BA18
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, IHC, MA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peroxiredoxin 4
Introduction
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. Diseases associated with PRDX4 include Scurvy and Cryptorchidism. Among its related pathways are Selenium Micronutrient Network and Prostaglandin 2 biosynthesis and metabolism FM.
Entrez Gene ID
10549
UniProt ID
Q13162
Alternative Names
PRX-4; AOE372; AOE37-2; HEL-S-97n
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationIEA:Ensembl
I-kappaB phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of male germ cell proliferationIEA:Ensembl
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIEA:Ensembl
Protein maturation by protein foldingIEA:Ensembl
Reactive oxygen species metabolic processIEA:Ensembl
Response to oxidative stressIEA:Ensembl
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
Endoplasmic reticulum
Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.
PTM
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRDX4 Antibody (10BA18)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare