PRG2

PRG2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions.
Full Name
Proteoglycan 2, Pro Eosinophil Major Basic Protein
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Biological Process
Defense response to bacteriumIEA:UniProtKB-KW
Defense response to nematodeIEA:Ensembl
Immune responseIEA:InterPro
Negative regulation of interleukin-10 productionIEA:Ensembl
Negative regulation of macrophage cytokine productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl
Cellular Location
Bone marrow proteoglycan
Secreted
The proform is secreted.
Eosinophil granule major basic protein
Cytoplasmic vesicle, secretory vesicle
The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
PTM
Nitrated.
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Anti-PRG2 antibodies

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Mouse Anti-PRG2 Recombinant Antibody (BMK13) (CBMAB-P2770-YC)

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Target: PRG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BMK13
Application*: E, C, P, WB
Datasheet SDS

Mouse Anti-PRG2 Recombinant Antibody (CBYC-P607) (CBMAB-P2771-YC)

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Target: PRG2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P607
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-PRG2 Recombinant Antibody (CBFYM-3074) (CBMAB-M3270-FY)

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Target: PRG2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-3074
Application*: WB, IC, C, P, E
Datasheet SDS

Mouse Anti-PRG2 Recombinant Antibody (CBFYE-1603) (CBMAB-E2260-FY)

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Target: PRG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1603
Application*: E, WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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