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PRG2

PRG2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions.

Full Name

Proteoglycan 2, Pro Eosinophil Major Basic Protein

Function

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Biological Process

Defense response to bacteriumIEA:UniProtKB-KW
Defense response to nematodeIEA:Ensembl
Immune responseIEA:InterPro
Negative regulation of interleukin-10 productionIEA:Ensembl
Negative regulation of macrophage cytokine productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl

Cellular Location

Bone marrow proteoglycan
Secreted
The proform is secreted.
Eosinophil granule major basic protein
Cytoplasmic vesicle, secretory vesicle
The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

PTM

Nitrated.

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Anti-PRG2 antibodies

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Mouse Anti-PRG2 Recombinant Antibody (BMK13) (CBMAB-P2770-YC)

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Target: PRG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BMK13

Application*: E, C, P, WB

Human Recombinant PRG2 protein, His Tag (V2LY-0526-LY6293)

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Target: PRG2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-222

Tag: His Tag

Mouse Anti-PRG2 Recombinant Antibody (CBYC-P607) (CBMAB-P2771-YC)

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Target: PRG2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P607

Application*: E, IC, WB

Mouse Anti-PRG2 Recombinant Antibody (CBFYM-3074) (CBMAB-M3270-FY)

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Target: PRG2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-3074

Application*: WB, IC, C, P, E

Mouse Anti-PRG2 Recombinant Antibody (CBFYE-1603) (CBMAB-E2260-FY)

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Target: PRG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1603

Application*: E, WB, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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