Mouse Anti-PRG2 Recombinant Antibody (CBFYM-3074) (CBMAB-M3270-FY)

Name: Mouse Anti-PRG2 Recombinant Antibody (CBFYM-3074)
SKU: CBMAB-M3270-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYM-3074

Application

WB, ICC, IHC-Fr, IHC-P, ELISA

Immunogen

The antibody is a mouse monoclonal antibody raised against MBP

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proteoglycan 2, Pro Eosinophil Major Basic Protein

Introduction

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule.

Entrez Gene ID

5553

UniProt ID

P13727

Alternative Names

MBP; BMPG; MBP1; proMBP

Function

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Biological Process

Defense response to bacteriumIEA:UniProtKB-KW
Defense response to nematodeIEA:Ensembl
Immune responseIEA:InterPro
Negative regulation of interleukin-10 productionIEA:Ensembl
Negative regulation of macrophage cytokine productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl

Cellular Location

Bone marrow proteoglycan
Secreted
The proform is secreted.
Eosinophil granule major basic protein
Cytoplasmic vesicle, secretory vesicle
The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

PTM

Nitrated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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