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Mouse Anti-PRG2 Recombinant Antibody (CBFYM-3074) (CBMAB-M3270-FY)

This product is mouse antibody that recognizes PRG2. The antibody CBFYM-3074 can be used for immunoassay techniques such as: WB, ICC, IHC-Fr, IHC-P, ELISA.
See all PRG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3074
Antibody Isotype
IgG
Application
WB, ICC, IHC-Fr, IHC-P, ELISA

Basic Information

Immunogen
The antibody is a mouse monoclonal antibody raised against MBP
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteoglycan 2, Pro Eosinophil Major Basic Protein
Introduction
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule.
Entrez Gene ID
5553
UniProt ID
P13727
Alternative Names
MBP; BMPG; MBP1; proMBP
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Biological Process
Defense response to bacteriumIEA:UniProtKB-KW
Defense response to nematodeIEA:Ensembl
Immune responseIEA:InterPro
Negative regulation of interleukin-10 productionIEA:Ensembl
Negative regulation of macrophage cytokine productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl
Cellular Location
Bone marrow proteoglycan
Secreted
The proform is secreted.
Eosinophil granule major basic protein
Cytoplasmic vesicle, secretory vesicle
The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
PTM
Nitrated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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