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Mouse Anti-PRG2 Recombinant Antibody (CBYC-P607) (CBMAB-P2771-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteoglycan 2, Pro Eosinophil Major Basic Protein. The antibody can be used for immunoassay techniques, such as ELISA, ICC, WB.
See all PRG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P607
Antibody Isotype
IgG
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 105-222

Target

Full Name
Proteoglycan 2, Pro Eosinophil Major Basic Protein
Introduction
PRG2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions.
Entrez Gene ID
5553
UniProt ID
P13727
Alternative Names
BMPG; MBP; MBP1; proMBP
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Biological Process
Defense response to bacteriumIEA:UniProtKB-KW
Defense response to nematodeIEA:Ensembl
Immune responseIEA:InterPro
Negative regulation of interleukin-10 productionIEA:Ensembl
Negative regulation of macrophage cytokine productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl
Cellular Location
Bone marrow proteoglycan
Secreted
The proform is secreted.
Eosinophil granule major basic protein
Cytoplasmic vesicle, secretory vesicle
The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
PTM
Nitrated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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