PRSS3
PRSS3 is a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9.
Full Name
Serine Protease 3
Function
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.
Biological Process
Antimicrobial humoral responseTAS:Reactome
DigestionManual Assertion Based On ExperimentTAS:UniProtKB
Endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Zymogen activationManual Assertion Based On ExperimentIDA:UniProtKB
DigestionManual Assertion Based On ExperimentTAS:UniProtKB
Endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Zymogen activationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
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Anti-PRSS3 antibodies
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Target: PRSS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P673
Application*: N, WB
Target: PRSS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P672
Application*: E
Target: PRSS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: E
Target: Prss3
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-1599
Application*: IH
Target: Prss3
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJT-1598
Application*: WB
Target: PRSS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1597
Application*: N, WB
Target: PRSS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1596
Application*: N
Target: PRSS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1595
Application*: WB
Target: PRSS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1594
Application*: E
Target: PRSS3
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: PRSS3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-247
Target: PRSS3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-247
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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