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PSMA1

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Full Name
proteasome (prosome, macropain) subunit, alpha type, 1
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Biological Process
Immune system processIEA:UniProtKB-KW
Negative regulation of inflammatory response to antigenic stimulusIEA:Ensembl
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
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Anti-PSMA1 antibodies

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Mouse Anti-PSMA1 Recombinant Antibody (MCP20) (CBMAB-P3134-YC)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: MCP20
Application*: WB, IP, F, IC, IF
Datasheet SDS

Mouse Anti-PSMA1 Recombinant Antibody (3F12-2C9) (CBMAB-A7121-LY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F12-2C9
Application*: WB, E
Datasheet SDS

Mouse Anti-PSMA1 Recombinant Antibody (3D8) (CBMAB-A7120-LY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D8
Application*: WB, E
Datasheet SDS

Mouse Anti-PSMA1 Recombinant Antibody (1D9-1C7) (CBMAB-P3131-YC)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9-1C7
Application*: IF, WB
Datasheet SDS

Mouse Anti-PSMA1 (ESKVDPSKA) Monoclonal Antibody (CBFYR0463) (CBMAB-R0463-FY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0463
Application*: E
Datasheet SDS

Mouse Anti-PSMA1 (ESKVDPSKA) Monoclonal Antibody (CBFYR0462) (CBMAB-R0462-FY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0462
Application*: IH, E, WB
Datasheet SDS

Mouse Anti-PSMA1 Monoclonal Antibody (CBFYR0461) (CBMAB-R0461-FY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0461
Application*: IH, E, WB
Datasheet SDS

Mouse Anti-PSMA1 Monoclonal Antibody (CBFYR0460) (CBMAB-R0460-FY)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0460
Application*: IH, E, WB
Datasheet SDS

Mouse Anti-PSMA1 Recombinant Antibody (CBYC-P688) (CBMAB-P3130-YC)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBYC-P688
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-PSMA1 Recombinant Antibody (3G258) (CBMAB-P3129-YC)

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Target: PSMA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Cattle
Clone: 3G258
Application*: E, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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