PSMG1
PSMG1 (Proteasome Assembly Chaperone 1) is a protein coding gene. Diseases associated with PSMG1 include Down Syndrome and Thrombasthenia. Gene Ontology annotations related to this gene include proteasome binding.
Full Name
proteasome (prosome, macropain) assembly chaperone 1
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Biological Process
Cerebellar granule cell precursor proliferationIEA:Ensembl
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Proteasome core complex assemblyManual Assertion Based On ExperimentIBA:GO_Central
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Proteasome core complex assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum
PTM
Degraded by the proteasome upon completion of 20S proteasome maturation.
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Anti-PSMG1 antibodies
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Target: PSMG1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F2
Application*: E
Target: PSMG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-358670
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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