PTBP3

PTBP3 binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro.

Full Name

Polypyrimidine tract binding protein 3

Function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).

Biological Process

Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Erythrocyte maturationIEA:UniProtKB-KW
mRNA processingIEA:UniProtKB-KW
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell differentiationIEA:InterPro
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus

Anti-PTBP3 antibodies

Mouse Anti-PTBP3 Recombinant Antibody (CBYC-P739) (CBMAB-P3291-YC)

Datasheet

SDS

Target: PTBP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P739

Application*: E, IC, IH, WB

Mouse Anti-PTBP3 Recombinant Antibody (4C9) (CBMAB-P3290-YC)

Datasheet

SDS

Target: PTBP3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C9

Application*: E, IF, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)