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PTBP3

PTBP3 binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro.

Full Name

Polypyrimidine tract binding protein 3

Function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).

Biological Process

Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Erythrocyte maturationIEA:UniProtKB-KW
mRNA processingIEA:UniProtKB-KW
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell differentiationIEA:InterPro
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus

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Anti-PTBP3 antibodies

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Mouse Anti-PTBP3 Recombinant Antibody (CBYC-P739) (CBMAB-P3291-YC)

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Target: PTBP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P739

Application*: E, IC, IH, WB

Mouse Anti-PTBP3 Recombinant Antibody (4C9) (CBMAB-P3290-YC)

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Target: PTBP3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C9

Application*: E, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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