PTPN3

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.

Full Name

Protein tyrosine phosphatase, non-receptor type 3

Function

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Biological Process

Liver regenerationIEA:Ensembl
MAPK cascadeTAS:Reactome
Negative regulation of epidermal growth factor receptor signaling pathwayTAS:Reactome
Negative regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of membrane depolarization during action potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cell membrane
Cytoplasm, cytoskeleton