PTTG1

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq]
Full Name
pituitary tumor-transforming 1
Function
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Biological Process
Cell divisionIEA:UniProtKB-KW
Chromosome organizationIEA:InterPro
DNA repairIEA:UniProtKB-KW
Homologous chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of mitotic sister chromatid separationManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
PTM
Phosphorylated at Ser-165 by CDK1 during mitosis.
Phosphorylated in vitro by ds-DNA kinase.
Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
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Anti-PTTG1 antibodies

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Rabbit Anti-PTTG1 Recombinant Antibody (D2B6O) (CBMAB-CP2386-LY)

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Target: PTTG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D2B6O
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (3H8) (CBMAB-A7250-LY)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H8
Application*: E, E
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (3H4) (CBMAB-A7249-LY)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 3H4
Application*: E, E
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (3F9) (CBMAB-A7248-LY)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F9
Application*: WB, E
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (4E5) (CBMAB-A7244-LY)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E5
Application*: WB, E
Datasheet SDS

Rabbit Anti-PTTG1 Recombinant Antibody (CBXS-1480) (CBMAB-S4333-CQ)

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Target: PTTG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1480
Application*: WB, IP, P, IC, F
Datasheet SDS

Rabbit Anti-PTTG1 Recombinant Antibody (CBXS-5367) (CBMAB-S2580-CQ)

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Target: PTTG1
Host: Rabbit
Specificity: Human
Clone: CBXS-5367
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (CBXS-4434) (CBMAB-S1676-CQ)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-4434
Application*: E, WB
Datasheet SDS

Rabbit Anti-PTTG1 Recombinant Antibody (CBXS-3787) (CBMAB-S1058-CQ)

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Target: PTTG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXS-3787
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (CBYC-P793) (CBMAB-P3507-YC)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-P793
Application*: E, WB
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (DCS-280) (CBMAB-P3506-YC)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: DCS-280
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (2C3) (CBMAB-P3505-YC)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2C3
Application*: E, WB
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (1G10) (CBMAB-P3504-YC)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G10
Application*: E, IF
Datasheet SDS

Mouse Anti-PTTG1 Recombinant Antibody (1D9) (CBMAB-P3503-YC)

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Target: PTTG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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