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PXK

PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM

Full Name

PX domain containing serine/threonine kinase

Function

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Biological Process

Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Modulation of chemical synaptic transmissionISS:UniProtKB
Negative regulation of ATP-dependent activityManual Assertion Based On ExperimentISS:UniProtKB
Negative regulation of ion transportManual Assertion Based On ExperimentISS:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Also associates with the plasma membrane. Isoform 3 is present throughout the cell.

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Anti-PXK antibodies

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Mouse Anti-PXK Recombinant Antibody (4D11) (CBMAB-P3553-YC)

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Target: PXK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4D11

Application*: E, WB

Human PXK ELISA Kit (V2LY-0626-LY5150)

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Target: PXK

Sensitivity: 0.009 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant Pxk protein, GST Tag (V2LY-0526-LY6428)

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Target: Pxk

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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