QRICH2

QRICH2 is a protein that in humans is edcoded by the QRICH2 gene on human chromosome 17. The function of QRICH2 protein is mostly unknown, but it has been shown that QRICH2 gene contains a high molecular weight Glutenin domain and an ATPase involved domain. QRICH2 gene is highly expressed in testis, and the subcellular location of QRICH2 protein is in the nucleus.

Full Name

Glutamine Rich 2

Function

Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.

Biological Process

Biological Process cell projection assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process flagellated sperm motilityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus membrane
Nucleus
Cytoplasm
Cell projection, cilium, flagellum
Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa.

Involvement in disease

Spermatogenic failure 35 (SPGF35):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in multiple abnormalities of sperm flagellum and severely impaired spermatozoa motility.