RAB31

Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]

Full Name

RAB31, Member RAS Oncogene Family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Biological Process

Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phagocytosis, engulfmentISS:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulated exocytosisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Golgi apparatus, trans-Golgi network
Golgi apparatus, trans-Golgi network membrane
Early endosome
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).