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Mouse Anti-RAB31 Recombinant Antibody (4D12) (CBMAB-R0816-CN)

This product is a Mouse antibody that recognizes RAB31. The antibody 4D12 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all RAB31 antibodies
Published Data
Fig. 1 Immunoprecipitation of p75NTR with Rab31 and Rab5 in 3T3L1 adipocytes stimulated with insulin. Lysates were immunoprecipitated with anti-p75NTR antibody, and Western blots were developed with anti-Rab31 and anti-Rab5 antibodies.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D12
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 96-195 from human RAB31 (H01148) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB31, Member RAS Oncogene Family
Introduction
Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]). [supplied by OMIM, Jul 2009]
Entrez Gene ID
11031
UniProt ID
Q13636
Alternative Names
RAB31, Member RAS Oncogene Family; Ras-Related Protein Rab-22B; Rab22B; Ras-Related Protein Rab-31;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Biological Process
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phagocytosis, engulfmentISS:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulated exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Golgi apparatus, trans-Golgi network
Golgi apparatus, trans-Golgi network membrane
Early endosome
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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