RABL6

This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

RAB, Member RAS Oncogene Family Like 6

May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.

Isoform 1
Cytoplasm
Predominantly cytoplasmic (PubMed:17962191).
Isoform 3
Nucleus
Predominantly nuclear (PubMed:17962191).

Isoform 1 is O-glycosylated, while other isoforms are not.