RANBP9

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

RAN Binding Protein 9

May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924).
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972).
May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085).
Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692).
Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118).
Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019).
Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process microtubule nucleationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of amyloid precursor protein catabolic processISS:ARUK-UCL
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc

Cytoplasm
Nucleus
Cell membrane
The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.

Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).
Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.