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Mouse Anti-RANBP9 Recombinant Antibody (13k114) (CBMAB-R1279-CN)

This product is a Mouse antibody that recognizes RANBP9. The antibody 13k114 can be used for immunoassay techniques such as: ICC, IP, WB.
See all RANBP9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13k114
Antibody Isotype
IgG1
Application
ICC, IP, WB

Basic Information

Immunogen
Purified recombinant human RANBP9 protein fragments expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1M Tris-Glycine, pH 7.4, 0.15M NaCl, 50% Glycerol
Preservative
0.2% sodium azide

Target

Full Name
RAN Binding Protein 9
Introduction
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
Entrez Gene ID
10048
UniProt ID
Q96S59
Alternative Names
RAN Binding Protein 9; Ran Binding Protein In The Microtubule Organizing Center; Ran-Binding Protein M; RANBP7; RANBPM; BPM-L;
Function
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924).
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972).
May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085).
Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692).
Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118).
Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019).
Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process microtubule nucleationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of amyloid precursor protein catabolic processISS:ARUK-UCL
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Cell membrane
The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
PTM
Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).
Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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