RFK

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]). [supplied by OMIM, Nov 2009]

Full Name

Riboflavin Kinase

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.

Biological Process

Biological Process apoptotic processManual Assertion Based On ExperimentIMP:MGI
Biological Process FMN biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process positive regulation of NAD(P)H oxidase activityManual Assertion Based On ExperimentIMP:MGI
Biological Process reactive oxygen species metabolic processIEA:Ensembl
Biological Process riboflavin biosynthetic process1 PublicationNAS:UniProtKB
Biological Process riboflavin metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm