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Mouse Anti-RFK Recombinant Antibody (E-7) (CBMAB-R2341-CN)

This product is a Mouse antibody that recognizes RFK. The antibody E-7 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RFK antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
E-7
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Riboflavin Kinase
Introduction
Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]). [supplied by OMIM, Nov 2009]
Entrez Gene ID
Human55312
Mouse54391
Rat499328
UniProt ID
HumanQ969G6
MouseQ8CFV9
RatQ6AYA7
Alternative Names
Riboflavin Kinase; ATP:Riboflavin 5-Phosphotransferase; Flavokinase; 0610038L10Rik; EC 2.7.1.26; RIFK;
Function
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Biological Process
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:MGI
Biological Process FMN biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process positive regulation of NAD(P)H oxidase activityManual Assertion Based On ExperimentIMP:MGI
Biological Process reactive oxygen species metabolic processIEA:Ensembl
Biological Process riboflavin biosynthetic process1 PublicationNAS:UniProtKB
Biological Process riboflavin metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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