RIOX1

RIOX1 (Ribosomal Oxygenase 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is RIOX2.
Full Name
RIOX1
Function
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity).
May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K36 demethylationISS:UniProtKB
Biological Process histone H3-K4 demethylationISS:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedISS:UniProtKB
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
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Anti-RIOX1 antibodies

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Mouse Anti-RIOX1 Recombinant Antibody (16F1) (CBMAB-0787-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16F1
Application*: E, M
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (14F1) (CBMAB-0786-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14F1
Application*: E, M
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (13A1) (CBMAB-0785-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13A1
Application*: E, M
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (12C9) (CBMAB-0784-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 12C9
Application*: E, M
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (11F3) (CBMAB-0783-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11F3
Application*: E, M
Datasheet SDS

Rabbit Anti-RIOX1 Recombinant Antibody (D7C8E) (CBMAB-CP1736-LY)

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Target: RIOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D7C8E
Application*: WB
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (CBLC243-LY) (CBMAB-C12147-LY)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLC243-LY
Application*: WB
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (8C75) (CBMAB-C4217-CN)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8C75
Application*: DB, WB
Datasheet SDS

Rabbit Anti-RIOX1 Recombinant Antibody (CBWJC-4376) (CBMAB-C5757WJ)

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Target: RIOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-4376
Application*: WB, IP
Datasheet SDS

Mouse Anti-RIOX1 Recombinant Antibody (3354C5a) (CBMAB-C0993-LY)

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Target: RIOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3354C5a
Application*: DB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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