Mouse Anti-RIOX1 Recombinant Antibody (11F3) (CBMAB-0783-CN)

Name: Mouse Anti-RIOX1 Recombinant Antibody (11F3)
SKU: CBMAB-0783-CN
Rating: 5 (1 reviews)

See all RIOX1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

11F3

Application

ELISA, MA

Immunogen

Recombinant protein of NO66 (aa. 167-641)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

RIOX1

Introduction

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1) residues, while it has weaker activity for dimethylated H3 Lys-36 (H3K36me2). This protein is highly conserved during evolution and shows in most cells analyzed a dual localization pattern, i.e., a strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities.

Entrez Gene ID

79697

UniProt ID

Q9H6W3

Alternative Names

ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity).
May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Biological Process

Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K36 demethylationISS:UniProtKB
Biological Process histone H3-K4 demethylationISS:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedISS:UniProtKB

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm
Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-RIOX1 Recombinant Antibody (11F3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RIOX1 Recombinant Antibody (14F1) (CAT#: CBMAB-0786-CN)

Mouse Anti-RIOX1 Recombinant Antibody (13A1) (CAT#: CBMAB-0785-CN)

Mouse Anti-RIOX1 Recombinant Antibody (16F1) (CAT#: CBMAB-0787-CN)

Mouse Anti-RIOX1 Recombinant Antibody (12C9) (CAT#: CBMAB-0784-CN)

Rabbit Anti-RIOX1 Recombinant Antibody (CBWJC-4376) (CAT#: CBMAB-C5757WJ)

Mouse Anti-RIOX1 Recombinant Antibody (8C75) (CAT#: CBMAB-C4217-CN)

Rabbit Anti-RIOX1 Recombinant Antibody (D7C8E) (CAT#: CBMAB-CP1736-LY)

Mouse Anti-RIOX1 Recombinant Antibody (3354C5a) (CAT#: CBMAB-C0993-LY)

Mouse Anti-RIOX1 Recombinant Antibody (CBLC243-LY) (CAT#: CBMAB-C12147-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry