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Mouse Anti-RIOX1 Recombinant Antibody (11F3) (CBMAB-0783-CN)

This product is a mouse antibody that recognizes RIOX1 of human. The antibody 11F3 can be used for immunoassay techniques such as: ELISA, MA.
See all RIOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11F3
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein of NO66 (aa. 167-641)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RIOX1
Introduction
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1) residues, while it has weaker activity for dimethylated H3 Lys-36 (H3K36me2). This protein is highly conserved during evolution and shows in most cells analyzed a dual localization pattern, i.e., a strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities.
Entrez Gene ID
79697
UniProt ID
Q9H6W3
Alternative Names
ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
Function
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity).
May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K36 demethylationISS:UniProtKB
Biological Process histone H3-K4 demethylationISS:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedISS:UniProtKB
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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