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Rabbit Anti-RIOX1 Recombinant Antibody (CBWJC-4376) (CBMAB-C5757WJ)

This product is a Rabbit antibody that recognizes RIOX1. This antibody CBWJC-4376 can be used for immunoassay techniques such as: WB, IP.
See all RIOX1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJC-4376
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RIOX1
Introduction
RIOX1 (Ribosomal Oxygenase 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is RIOX2.
Entrez Gene ID
Human79697
Mouse71952
Rat314300
UniProt ID
HumanQ9H6W3
MouseQ9JJF3
RatD3ZU57
Alternative Names
Ribosomal Oxygenase 1; Nucleolar Protein 66; Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase NO66; 0S Ribosomal Protein L8 Histidine Hydroxylase; Myc-Associated Protein With JmjC Domain; Histone Lysine Demethylase NO66; Ribosomal Oxygenase NO66; C14orf169; HsNO66; MAPJD; NO66;
Function
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity).
May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K36 demethylationISS:UniProtKB
Biological Process histone H3-K4 demethylationISS:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedISS:UniProtKB
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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