RNF181

RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Full Name
Ring Finger Protein 181
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:18331836).
Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749).
Biological Process
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Autoubiquitinated as part of the enzymatic reaction.
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Anti-RNF181 antibodies

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Mouse Anti-RNF181 Recombinant Antibody (CBYJL-2334) (CBMAB-L2636-YJ)

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Target: RNF181
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-2334
Application*: WB
Datasheet SDS

RNF181 Matched Antibody Pair (1010) (APMAB-1010LY)

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Target: RNF181
Specificity: Human
Datasheet SDS

RNF181 Matched Antibody Pair (1009) (APMAB-1009LY)

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Target: RNF181
Specificity: Human
Datasheet SDS

Mouse Anti-RNF181 Recombinant Antibody (F-2) (CBMAB-R2971-CN)

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Target: RNF181
Host: Mouse
Specificity: Human
Clone: F-2
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-RNF181 Recombinant Antibody (5A7) (CBMAB-R2970-CN)

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Target: RNF181
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A7
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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