RNF181
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Full Name
Ring Finger Protein 181
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:18331836).
Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749).
Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749).
Biological Process
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Autoubiquitinated as part of the enzymatic reaction.
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Anti-RNF181 antibodies
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CompareTarget: RNF181
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-2334
Application*: WB
Target: RNF181
Specificity: Human
Target: RNF181
Specificity: Human
Target: RNF181
Host: Mouse
Specificity: Human
Clone: F-2
Application*: WB, IP, IF, P, E
Target: RNF181
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A7
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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