RNF41

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Full Name

Ring Finger Protein 41

Function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity).
Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity).
Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Biological Process

Biological Process autophagyIEA:UniProtKB-KW
Biological Process extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:MGI
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of mitophagyIEA:Ensembl
Biological Process positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process proteasomal protein catabolic processManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lymphocyte differentiationIEA:Ensembl
Biological Process regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of myeloid cell differentiationIEA:Ensembl
Biological Process regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

cytosol
endoplasmic reticulum tubular network
perinuclear region of cytoplasm

PTM

Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.