RPL3

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Full Name

Ribosomal Protein L3

Function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547).

Biological Process

Biological Process cellular response to interleukin-4IEA:Ensembl
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process translationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus
Cytoplasm

PTM

Constitutively monomethylated at His-245 by METTL18 (PubMed:23349634, PubMed:33693809).
Regulates the function of RPL3 in the dynamics of pre-rRNA processing, ribosome biogenesis, and translation (PubMed:33693809).
It is not required for incorporation of RPL3 into ribosomes (PubMed:33693809).