RRBP1

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

Ribosome Binding Protein 1

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Endoplasmic reticulum membrane

Lumenal: 1-7
Helical: 8-28
Cytoplasmic: 29-1410