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RRBP1

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

Full Name

Ribosome Binding Protein 1

Function

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Biological Process

Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 1-7
Helical: 8-28
Cytoplasmic: 29-1410

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Anti-RRBP1 antibodies

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Mouse Anti-RRBP1 Recombinant Antibody (P5610) (CBMAB-R3657-CN)

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Target: RRBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: P5610

Application*: ICC, IF, WB

Mouse Anti-RRBP1 Recombinant Antibody (P1611) (CBMAB-R3656-CN)

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Target: RRBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: P1611

Application*: WB

Mouse Anti-RRBP1 Recombinant Antibody (5610) (CBMAB-R3655-CN)

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Target: RRBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5610

Application*: WB, IF

Mouse Anti-RRBP1 Recombinant Antibody (3F1) (CBMAB-R3654-CN)

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Target: RRBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F1

Application*: WB, IH

Mouse Anti-RRBP1 Recombinant Antibody (1611) (CBMAB-R3653-CN)

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Target: RRBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1611

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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