RUFY1

This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Full Name
RUN and FYVE domain containing 1
Function
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Biological Process
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process small GTPase mediated signal transductionIEA:Ensembl
Cellular Location
Cytoplasm
Early endosome membrane
PTM
Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.
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Anti-RUFY1 antibodies

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Mouse Anti-RUFY1 Recombinant Antibody (CBXS-3260) (CBMAB-S6001-CQ)

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Target: RUFY1
Host: Mouse
Specificity: Human
Clone: CBXS-3260
Application*: E, WB
Datasheet SDS

Mouse Anti-RUFY1 Recombinant Antibody (CBCNR-870) (CBMAB-R3830-CN)

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Target: RUFY1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-870
Application*: WB
Datasheet SDS

Mouse Anti-RUFY1 Recombinant Antibody (A-4) (CBMAB-R3829-CN)

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Target: RUFY1
Host: Mouse
Specificity: Human
Clone: A-4
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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