RUFY1

This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

RUN and FYVE domain containing 1

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.

Biological Process endocytosisIEA:UniProtKB-KW
Biological Process protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process small GTPase mediated signal transductionIEA:Ensembl

Cytoplasm
Early endosome membrane

Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.