SCARF1

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants.

Scavenger Receptor Class F Member 1

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process cholesterol catabolic process1 PublicationIC:UniProtKB
Biological Process dendrite developmentIEA:Ensembl
Biological Process neuron remodelingISS:UniProtKB
Biological Process positive regulation of axon regenerationISS:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB

Membrane

Extracellular: 20-421
Helical: 422-442
Cytoplasmic: 443-830