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SCARF1

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants.

Full Name

Scavenger Receptor Class F Member 1

Function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

Biological Process

Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process cholesterol catabolic process1 PublicationIC:UniProtKB
Biological Process dendrite developmentIEA:Ensembl
Biological Process neuron remodelingISS:UniProtKB
Biological Process positive regulation of axon regenerationISS:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 20-421
Helical: 422-442
Cytoplasmic: 443-830

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Anti-SCARF1 antibodies

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Mouse Anti-SCARF1 Recombinant Antibody (CBXS-3434) (CBMAB-S6165-CQ)

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Target: SCARF1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-3434

Application*: E, F, WB

Rabbit Anti-SCARF1 Recombinant Antibody (CBXS-1500) (CBMAB-S4353-CQ)

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Target: SCARF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1500

Application*: WB, IP, P, IC

Mouse Anti-SCARF1 Recombinant Antibody (CBXS-0134) (CBMAB-S3125-CQ)

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Target: SCARF1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-0134

Application*: E, F, WB

Mouse Anti-SCARF1 Recombinant Antibody (CBXS-1804) (CBMAB-S0117-CQ)

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Target: SCARF1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1804

Application*: F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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