SEPHS2

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3' UTR of the gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct the incorporation of selenocysteine rather than signal a translational stop. Alternatively spliced transcripts have been identified, but their biological validity has not been determined. [provided by RefSeq]

Full Name

selenophosphate synthetase 2

Function

Synthesizes selenophosphate from selenide and ATP.

Biological Process

Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process selenium compound metabolic processIEA:Ensembl
Biological Process selenocysteine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process selenocysteine metabolic processTAS:Reactome

Cellular Location

cytoplasm
cytosol

PTM

Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins.