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Mouse Anti-SEPHS2 Recombinant Antibody (CBXS-4637) (CBMAB-S1876-CQ)

This product is a mouse antibody that recognizes SEPHS2. The antibody CBXS-4637 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all SEPHS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4637
Antibody Isotype
IgG
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
selenophosphate synthetase 2
Introduction
This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5.
Entrez Gene ID
22928
UniProt ID
Q99611
Alternative Names
Selenophosphate Synthetase 2; Selenophosphate Synthase 2; Selenium Donor Protein 2; EC 2.7.9.3; SPS2; Selenide, Water Dikinase 2;
Function
Synthesizes selenophosphate from selenide and ATP.
Biological Process
Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process selenium compound metabolic processIEA:Ensembl
Biological Process selenocysteine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process selenocysteine metabolic processTAS:Reactome
Cellular Location
cytoplasm
cytosol
PTM
Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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