Mouse Anti-SEPHS2 Recombinant Antibody (CBXS-4637) (CBMAB-S1876-CQ)

Name: Mouse Anti-SEPHS2 Recombinant Antibody (CBXS-4637)
SKU: CBMAB-S1876-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4637

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

selenophosphate synthetase 2

Introduction

This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5.

Entrez Gene ID

22928

UniProt ID

Q99611

Alternative Names

Selenophosphate Synthetase 2; Selenophosphate Synthase 2; Selenium Donor Protein 2; EC 2.7.9.3; SPS2; Selenide, Water Dikinase 2;

Function

Synthesizes selenophosphate from selenide and ATP.

Biological Process

Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process selenium compound metabolic processIEA:Ensembl
Biological Process selenocysteine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process selenocysteine metabolic processTAS:Reactome

Cellular Location

cytoplasm
cytosol

PTM

Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SEPHS2 Recombinant Antibody (2G9) (CAT#: CBMAB-A7975-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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