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Mouse Anti-SEPHS2 Recombinant Antibody (2G9) (CBMAB-A7975-LY)

The product is antibody recognizes SEPHS2. The antibody 2G9 immunoassay techniques such as: WB, ELISA.
See all SEPHS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SEPHS2 (NP_036380.2, 61 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
selenophosphate synthetase 2
Introduction
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3' UTR of the gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct the incorporation of selenocysteine rather than signal a translational stop. Alternatively spliced transcripts have been identified, but their biological validity has not been determined. [provided by RefSeq]
Entrez Gene ID
22928
UniProt ID
Q99611
Alternative Names
SPS2
Function
Synthesizes selenophosphate from selenide and ATP.
Biological Process
Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process selenium compound metabolic processIEA:Ensembl
Biological Process selenocysteine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process selenocysteine metabolic processTAS:Reactome
Cellular Location
cytoplasm
cytosol
PTM
Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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