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SERPINB6

The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
Full Name
serpin family B member 6
Function
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity).
Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Biological Process
Biological Process cellular response to osmotic stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal recessive, 91 (DFNB91):
A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
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Anti-SERPINB6 antibodies

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Mouse Anti-SERPINB6 Recombinant Antibody (3A) (CBMAB-P3651-YC)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3A
Application*: IF, IP, E, F
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-2427) (CBMAB-S5184-CQ)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2427
Application*: F, IF, IP
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-0245) (CBMAB-S3222-CQ)

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Target: SERPINB6
Host: Mouse
Specificity: Human
Clone: CBXS-0245
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-4939) (CBMAB-S2161-CQ)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4939
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-4724) (CBMAB-S1954-CQ)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4724
Application*: E, F, IP
Datasheet SDS

Rabbit Anti-SERPINB6 Recombinant Antibody (CBXS-4681) (CBMAB-S1916-CQ)

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Target: SERPINB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4681
Application*: E
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-4605) (CBMAB-S1845-CQ)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4605
Application*: P, WB
Datasheet SDS

Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-3929) (CBMAB-S1194-CQ)

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Target: SERPINB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Monkey
Clone: CBXS-3929
Application*: WB, F, IH, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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