Mouse Anti-SERPINB6 Recombinant Antibody (3A) (CBMAB-P3651-YC)

Name: Mouse Anti-SERPINB6 Recombinant Antibody (3A)
SKU: CBMAB-P3651-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

Application

IF, IP, ELISA, FC

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS with 0.05% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

serpin family B member 6

Introduction

SERPINB6 is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss.

Entrez Gene ID

5269

UniProt ID

P35237

Alternative Names

Serpin Family B Member 6; Cytoplasmic Antiproteinase; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 6; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6; PI-6; CAP; PI6; PTI; Protease Inhibitor 6 (Placental Thrombin Inhibitor);

Function

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity).
Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Biological Process

Biological Process cellular response to osmotic stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Deafness, autosomal recessive, 91 (DFNB91):
A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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