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Mouse Anti-SERPINB6 Recombinant Antibody (CBXS-3929) (CBMAB-S1194-CQ)

This product is a mouse antibody that recognizes SERPINB6. The antibody CBXS-3929 can be used for immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all SERPINB6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Monkey
Clone
CBXS-3929
Antibody Isotype
IgG2a
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Recombinant full length human SERPINB6(NP_004559)
Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serpin family B member 6
Introduction
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human5269
Mouse20719
Monkey716411
UniProt ID
HumanP35237
MouseQ60854
MonkeyH9H396
Alternative Names
Serpin Family B Member 6; Cytoplasmic Antiproteinase; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 6; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6; PI-6; CAP; PI6; PTI; Protease Inhibitor 6 (Placental Thrombin Inhibitor);
Function
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity).
Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Biological Process
Biological Process cellular response to osmotic stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal recessive, 91 (DFNB91):
A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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