SERPINH1
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Full Name
Serpin Family H Member 1
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Biological Process
Biological Process chondrocyte development involved in endochondral bone morphogenesisIEA:Ensembl
Biological Process collagen biosynthetic processIEA:Ensembl
Biological Process collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein maturationIEA:Ensembl
Biological Process response to unfolded proteinManual Assertion Based On ExperimentTAS:ProtInc
Biological Process collagen biosynthetic processIEA:Ensembl
Biological Process collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein maturationIEA:Ensembl
Biological Process response to unfolded proteinManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Endoplasmic reticulum lumen:
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI10 is an autosomal recessive form characterized by multiple bone deformities and fractures, generalized osteopenia, dentinogenesis imperfecta, and blue sclerae.
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI10 is an autosomal recessive form characterized by multiple bone deformities and fractures, generalized osteopenia, dentinogenesis imperfecta, and blue sclerae.
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Anti-SERPINH1 antibodies
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CompareTarget: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1426
Application*: ICC/IF, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1425
Application*: ICC/IF, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 1D2-1A6
Application*: WB, E
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Rabbit, Guinea pig, Pig, Sheep
Clone: M16.10A1
Application*: WB, P
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0269
Application*: P, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBXS-0268
Application*: E, P, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Mouse, Rat, Rabbit, Chicken, Guinea pig, Monkey, Dog, Pig, Sheep, Hamster
Clone: CBXS-0267
Application*: E, WB, P
Target: SERPINH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-5478
Application*: WB, P, IF
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3979
Application*: E, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3926
Application*: IC, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 134CT3.1.1
Application*: E, IH, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-3111
Application*: WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 134CT3-1-1
Application*: P, WB
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2757
Application*: WB, P, F, IF
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2756
Application*: WB, E
Target: SERPINH1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYH-2754
Application*: WB, IP, IF, E
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2752
Application*: WB, IH, IC
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Pig, Cattle, Dog, Chicken, Guinea pig, Hamster, Monkey, Rabbit, Sheep
Clone: CBFYH-3305
Application*: WB, F, IH, IF, IP, P, C
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBFYH-3304
Application*: WB, F
Target: SERPINH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3303
Application*: WB, IF
Target: SERPINH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10B2
Application*: E, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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