SFTPD
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
Full Name
Surfactant Protein D
Function
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Biological Process
Biological Process defense response to bacteriumManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process induction of bacterial agglutinationManual Assertion Based On ExperimentIMP:AgBase
Biological Process innate immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process lung alveolus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation by host of symbiont catalytic activityManual Assertion Based On ExperimentIDA:AgBase
Biological Process negative regulation of interleukin-2 productionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reactive oxygen species metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of adhesion of symbiont to host epithelial cellManual Assertion Based On ExperimentIDA:AgBase
Biological Process regulation of cytokine production1 PublicationNAS:UniProtKB
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Biological Process surfactant homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process induction of bacterial agglutinationManual Assertion Based On ExperimentIMP:AgBase
Biological Process innate immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process lung alveolus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation by host of symbiont catalytic activityManual Assertion Based On ExperimentIDA:AgBase
Biological Process negative regulation of interleukin-2 productionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reactive oxygen species metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of adhesion of symbiont to host epithelial cellManual Assertion Based On ExperimentIDA:AgBase
Biological Process regulation of cytokine production1 PublicationNAS:UniProtKB
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Biological Process surfactant homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix
Secreted, extracellular space, surface film
Secreted, extracellular space, surface film
PTM
The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
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Anti-SFTPD antibodies
+ Filters
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CompareTarget: SFTPD
Specificity: Human
Target: SFTPD
Specificity: Human
Target: SFTPD
Specificity: Human
Target: SFTPD
Specificity: Human
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: CBHb386
Application*: Immuno assays, IHC-P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBHb385
Application*: Immuno assays, IHC-P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C10
Application*: WB, E
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A10
Application*: WB, E
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: VIF9
Application*: IA, P, WB
Target: SFTPD
Host: Mouse
Specificity: Rat
Clone: VIF11
Application*: P
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: SPDE
Application*: C, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: IVG8
Application*: E, P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-3341
Application*: E, IH, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-2982
Application*: E, IH, WB
Target: SFTPD
Host: Mouse
Specificity: Human
Clone: CBXS-2854
Application*: E, IF, WB
Target: SFTPD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBXS-1050
Application*: P
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0993
Application*: E, WB, P
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-0329
Application*: IA, P, WB
Target: SFTPD
Host: Mouse
Specificity: Human
Clone: CBXS-0326
Application*: WB, IC, P, C, E
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0325
Application*: E, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0323
Application*: E, P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0321
Application*: E, C, P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 16C11
Application*: E, P, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 12g5
Application*: E, IH, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10B2
Application*: E, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4332
Application*: E, P, WB
Target: SFTPD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3779
Application*: E, EC
Target: SFTPD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3647
Application*: P
Target: SFTPD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBXS-3638
Application*: E
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5825
Application*: E, WB
Target: SFTPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 1.7
Application*: WB, IH, IF, P, C
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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