SFTPD

The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]

Surfactant Protein D

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Biological Process defense response to bacteriumManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process induction of bacterial agglutinationManual Assertion Based On ExperimentIMP:AgBase
Biological Process innate immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process lung alveolus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation by host of symbiont catalytic activityManual Assertion Based On ExperimentIDA:AgBase
Biological Process negative regulation of interleukin-2 productionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reactive oxygen species metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of adhesion of symbiont to host epithelial cellManual Assertion Based On ExperimentIDA:AgBase
Biological Process regulation of cytokine production1 PublicationNAS:UniProtKB
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Biological Process surfactant homeostasisManual Assertion Based On ExperimentIMP:UniProtKB

Secreted, extracellular space, extracellular matrix
Secreted, extracellular space, surface film

The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.